Archive for January 27th, 2009

Ingredient Watch: Synthetic Fragrances II

January 27, 2009
Author: natural

Another article about synthetic fragrances from the Natrual Ingredient Resource Center:

Common Fragrance Ingredient Damages Connections Between Brain CellsMusk Ambrette is the name given to a commonly used fragrance ingredient, that according to researchers, causes serious brain damage in laboratory animals exposed to the chemical.

Musk Ambrette, whose chemical name is 2,6-dinitro-3-methoxy-4-tert-butyltoluene, is a common fixative ingredient that is currently added to fragrances in order to slow their evaporation, thereby making it more attractive to the consumer. It is found within most fragrances at a level of 1 to 3.5%. The chemical is also used to a lesser extent as an artificial flavor in compositions such as cherry, nut, spice vanilla, and mint.

The neurotoxic properties of Musk Ambrette are well established and as stated by the researchers,

“Musk ambrette, a nitro-musk compound widely used as a fixative in fragrance formulations and found to a lesser degree in flavor compositions, produces hindlimb weakness when administered in the diet or applied to skin of rats for periods up to 12 weeks. Underlying neuropathologic changes consist of primary demyelination and distal axonal degeneration in selected regions of the central and peripheral nervous system.”

 

 

Primary demyelination means that the insulative myelin sheath surrounding the nerve cell connections are slowly being worn away. Degeneration of the axons means the actual connection from brain cell to brain cell is being destroyed by the chemical.